Table 3

Frequency of autoantibody positivity in 0602+ and 0602− relatives at screening

0602+ (n = 155)0602− (n = 3,203)P
Entire data set (n = 3,203)
 GAD65A72.9 (113/155)80.4 (2,574/3,203)0.02
 IA-2A17.4 (27/155)35.5 (1,136/3,203)<0.0001
 mIAA29.7 (46/155)38.2 (1,124/3,203)0.03
 1 AAb84.5 (131/155)59.0 (1,890/3,203)<0.0001
 2 AAb11.0 (17/155)27.9 (895/3,203)<0.0001
 3 AAb4.5 (7/155)13.0 (418/3,203)<0.0001
0602+ (n = 85)0602− (n = 1,855)P
Subset tested for ZnT8A (n = 1,940)
 GAD65A78.2 (67/85)80.2 (1,488/1,855)0.75
 IA-2A18.8 (16/85)36.1 (670/1,855)0.001
 mIAA24.7 (21/85)39.0 (723/1,855)0.008
 ZnT8A12.9 (11/85)36.1 (669/1,855)<0.0001
 1 AAb81.2 (69/85)48.3 (896/1,855)<0.0001
 2 AAb8.2 (7/85)22.5 (418/1,855)<0.0001
 3 AAb4.7 (4/85)18.6 (346/1,855)<0.0001
 4 AAb5.9 (5/85)10.5 (195/1,855)<0.0001
  • Data are % (n/N), unless stated otherwise. AAb, autoantibody.