Table 2

The effect of pregnancy and gestational age on the biometry and biochemical composition in NP females and pregnant dams at D16 and D19 of pregnancy

Pregnant
NPD16D19
Biometry
 Total body weight (g)21.0 ± 0.4a (20)31.0 ± 1.1b (13)35.0 ± 1.2b (16)
 Hysterectomized weight (g)24.0 ± 0.7 (13)23.0 ± 0.8 (15)
 Liver (mg)1,099 ± 28a (10)1,903 ± 57b (13)1,856 ± 76b (16)
  (%)5.5 ± 0.2a (10)7.9 ± 0.1b (13)8.1 ± 0.3b (16)
 Kidney (mg)234.0 ± 6.5a (10)277 ± 12b (11)271 ± 11b (15)
  (%)1.20 ± 0.02 (10)1.10 ± 0.02 (11)1.20 ± 0.04 (15)
 Heart (mg)106.0 ± 6.5a (10)132 ± 5b (13)137 ± 7b (16)
  (%)0.50 ± 0.03 (10)0.50 ± 0.01 (13)0.60 ± 0.03 (16)
 Retroperitoneal fat (mg)30 ± 2a (16)73 ± 7b (13)63 ± 6b (16)
  (%)0.1 ± 2.0a (16)0.30 ± 0.03b (13)0.30 ± 0.03b (16)
 Gravid uterus (g)7.3 ± 0.4 (13)11.2 ± 0.7* (15)
 Placenta average per litter (mg)104.0 ± 1.8 (13)88.0 ± 2.7* (16)
 Fetus average per litter (mg)427 ± 12 (13)1,204 ± 17* (16)
 Litter size7.8 ± 0.5 (13)7.1 ± 0.4 (16)
Biochemical composition
 DEXA absolute fat mass (g)3.9 ± 0.2 (10)4.4 ± 0.3 (7)4.5 ± 0.2 (7)
 DEXA fat mass (%)17.6 ± 0.9 (10)17.8 ± 1.2 (7)19.2 ± 0.5 (7)
 DEXA absolute lean mass (g)18.2 ± 0.6a (10)20.3 ± 0.5b (7)18.7 ± 0.7a,b (10)
 DEXA lean mass (%)82.4 ± 0.9 (10)82.3 ± 1.2 (7)80.9 ± 0.5 (10)
 Hepatic glycogen (mg/g)55 ± 3 (15)49 ± 1 (6)57 ± 6 (6)
 Total hepatic glycogen (mg)61 ± 4a (15)86 ± 3b (6)103 ± 11b (6)
 Hepatic fat content (%)5.4 ± 0.3 (15)5.1 ± 0.3 (6)4.7 ± 0.3 (6)
 Total hepatic fat content (mg)59 ± 5a (15)91 ± 6b (6)86 ± 6b (6)
 Skeletal muscle fat content (%)§4.015.420.4
  • Data are expressed as mean ± SEM with the number of dams/litters in parentheses. Values with different superscript letters are significantly different from each other (P < 0.05, one-way ANOVA).

  • *Significant difference between D16 and D19 pregnant dams (P < 0.05, Student t test).

  • †Organ weights and DEXA results were expressed as percent of total body weight for NP females and of hysterectomized body weight for pregnant dams.

  • §Skeletal muscle fat content was measured on samples pooled from three to five animals from each group.