Table 7

Frequencies of HLA haplotypes in 0602+ and 0602− relatives

Haplotypes or genotypes0602+0602−0602+0602−
All AAb+Single AAb at screening and on follow-up
n/N%n/N%Pn/N%n/N%P
DRB1*03+, (DRB1*04−)57/15536.8725/2,44729.60.0748/11741.0440/1,26134.90.19
DRB1*03:01-DQA1*05:01-DQB1*02:01+, (DRB1*04−)54/15534.8720/2,44729.40.1845/11738.5437/1,26134.70.41
DRB1*04+, (DRB1*03−)54/15534.81,339/2,44754.7<0.000135/11729.9528/1,26141.90.01
DRB1*04-DQA1*03:01-DQB1*03:02+, (DRB1*03−)45/15529.01,136/2,44746.4<0.000129/11724.8445/1,26135.30.02
DRB1*04+ and DRB1*03+0/1550.0755/3,20323.6<0.00010/1170.0268/1,47718.1<0.0001
DRB1*04-DQA1*03:01-DQB1*03:02+ and DRB1*03:01-DQA1*05:01-DQB1*02:01+0/1550.0659/3,20320.6<0.00010/1170.0216/1,47714.6<0.0001
Single AAb at screening → multiple AAbMultiple AAb at screening
n/N%n/N%Pn/N%n/N%P
DRB1*03+, (DRB1*04−)4/1428.679/30925.60.765/2420.8206/97321.21.0
DRB1*03:01-DQA1*05:01-DQB1*02:01+, (DRB1*04−)4/1428.678/30925.20.755/2420.8205/97321.11.0
DRB1*04+, (DRB1*03−)7/1450.0188/30960.80.4112/2450.0623/97364.00.19
DRB1*04-DQA1*03:01-DQB1*03:02+, (DRB1*03−)6/1442.9165/30953.40.5810/2441.7526/97354.10.3
DRB1*04+ and DRB1*03+0/140.0115/41327.80.010/240.0373/1,31328.40.0007
DRB1*04-DQA1*03:01-DQB1*03:02+ and DRB1*03:01-DQA1*05:01-DQB1*02:01+0/140.0104/41325.20.020/240.0339/1,31325.80.001