Table 3

The effect of pregnancy and gestational age on blood glucose concentrations in the fed and fasted state and on plasma concentrations of FFAs, TGs, cholesterol, insulin, leptin, and IGF1 in NP females and dams at D16 and D19 of pregnancy in the fed state

NPPregnant
D16D19
Glucose (mmol/L)
 Fed9.3 ± 0.5 (10)10.3 ± 0.3 (11)9.4 ± 0.6 (16)
 Fasted 3.5 h7.1 ± 0.4a (8)5.3 ± 0.3b (6)5.5 ± 0.3b (6)
 Fasted 6 h6.9 ± 0.3a (11)6.8 ± 0.2a (9)5.2 ± 0.3b (8)
FFA fed (μmol/L)637 ± 49a (10)256 ± 42b (9)381 ± 41b* (10)
TG fed (mmol/L)1.0 ± 0.1 (10)1.2 ± 0.2 (9)1.0 ± 0.1 (10)
Cholesterol fed (mmol/L)1.8 ± 0.1a (10)1.4 ± 0.1b (9)1.0 ± 0.1c (10)
Insulin fed (μg/L)0.19 ± 0.04a (10)1.3 ± 0.3b (10)0.6 ± 0.1a,b (10)
Leptin fed (pg/mL)766 ± 71a (10)4,058 ± 656b (10)3,927 ± 709b (10)
IGF1 fed (pg/mL)487 ± 68a (10)299 ± 23b (12)253 ± 20b (12)
  • Data are expressed as mean ± SEM with the number of animals shown in parentheses. Values with different superscript letters are significantly different from each other (P < 0.05, one-way ANOVA).

  • *Significant difference between D16 and D19 of pregnancy (P < 0.05, Student t test).

  • †Significantly different values between animals fasted for 3.5 and 6 h in the same group.