TABLE 1

Analysis of inducible antiapoptotic genes expressed in islets from BALB/c or NOD mice

Gene symbolGene titleGenBank IDBasal expres-sionFold Δ IL-1/mediaP valueFold Δ TNF/mediaP value
BALB/c
    AatfApoptosis antagonizing transcription factorNM_0198161,356.20.7920.0760.7740.099
    AvenApoptosis caspase activation inhibitorNM_028844173.11.0040.9881.1000.758
    Birc1aBaculoviral IAP repeat-containing 1aNM_008670492.90.8730.6120.9160.771
    Birc1bBaculoviral IAP repeat-containing 1bNM_0108721,094.90.8360.2420.8540.170
    Birc1eBaculoviral IAP repeat-containing 1eNM_010870358.30.8040.3870.8710.579
    Birc1fBaculoviral IAP repeat-containing 1fNM_010871904.10.9630.8421.0380.839
    Birc2Baculoviral IAP repeat-containing 2*NM_0074651,069.41.0450.6351.1660.122
    Birc3Baculoviral IAP repeat-containing 3*NM_007464422.22.860.000045502.2520.00030850
    Birc4Baculoviral IAP repeat-containing 4*NM_009688490.20.8510.4970.8100.375
    Birc5Baculoviral IAP repeat-containing 5NM_0096891,462.41.0760.7101.0670.757
    Birc6Baculoviral IAP repeat-containing 6NM_007566715.61.0860.7551.2050.593
    Bcl2B-cell leukemia/lymphoma 2*NM_009741145.50.8540.3580.8720.312
    Bcl2a1aB-cell leukemia/lymphoma 2 related protein A1a*NM_009742297.41.2590.2301.1710.405
    Bcl2a1cB-cell leukemia/lymphoma 2 related protein A1cNM_007535421.31.50.0611.5170.058
    Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1dNM_007536269.31.2010.3851.1120.597
    Bcl3B-cell leukemia/lymphoma 3NM_0336011,067.21.2490.1371.4410.042
    Bag4BCL2-associated athanogene 4NM_026121242.70.6810.0170.8830.425
    Bcl2lBcl2-like*NM_009743347.50.8880.5000.9170.454
    Bcl2l10Bcl2-like 10NM_0134791,548.80.8830.5140.9750.865
    Bcl2l2Bcl2-like 2NM_0075371,140.70.8270.2150.9030.632
    BfarBifunctional apoptosis regulatorNM_0259761,554.30.9460.7470.9650.811
    Dad1Defender against cell death 1NM_0100158,589.70.8140.0730.8890.454
    Gpx1Glutathione peroxidase 1NM_0081603,801.61.2970.3341.4310.237
    Gpx2Glutathione peroxidase 2NM_0306772,112.70.9620.7940.8500.198
    Gpx4Glutathione peroxidase 4NM_0081624,202.21.0220.9151.0870.735
    Gpx5Glutathione peroxidase 5NM_0103433,446.10.9890.9240.9390.702
    Hras1Harvey rat sarcoma virus oncogene 1NM_0082842,0610.8610.1550.9200.418
    Hspa5Heat shock 70 kD protein 5 (glucose-regulated protein)*NM_02231010,768.61.070.7891.1830.586
    Hspe1Heat shock protein 1 (chaperonin 10)NM_0083033,781.10.9850.9501.1950.537
    Hspd1Heat shock protein 1 (chaperonin)NM_0104773,407.40.9750.8601.1270.449
    HspcaHeat shock protein 1 αNM_0104808,052.71.1020.7061.3570.268
    HspcbHeat shock protein 1 βNM_00830212,568.90.8870.4291.1440.416
    Hsp105Heat shock protein 105NM_0135592,763.31.0050.9851.4990.147
    Hspa12bHeat shock protein 12BNM_028306360.41.0230.8970.9760.896
    Hspa1aHeat shock protein 1AAW763765228.41.3380.6631.9420.271
    Hspa1bHeat shock protein 1BM125733,598.21.1390.7411.5060.238
    Hspa1lHeat shock protein 1-likeNM_013558437.90.8350.2860.8060.235
    Hspa2Heat shock protein 2NM_008301327.21.0280.8970.9860.958
    Hspb3Heat shock protein 3NM_019960516.50.970.8940.8700.408
    Hspa4Heat shock protein 4NM_0083002,515.11.0050.9781.1610.437
    Hspa8Heat shock protein 8NM_0311659,024.81.2330.4161.4560.199
    Hspb7Heat shock protein family member 7 (cardiovascular)NM_0138681,878.80.6560.1690.7130.217
    Hebp2Heme binding protein 2NM_0194872,216.50.7840.0680.7100.052
    Hmox1Heme oxygenase (decycling) 1*NM_0104425,708.60.9040.3170.8910.234
    Hmox2Heme oxygenase (decycling) 2NM_0104431,657.50.9390.6821.0340.866
    Hnf4Hepatic nuclear factor 4NM_008261895.20.9330.5811.0370.753
    Sod1Superoxide dismutase 1 soluble*BM240246228.61.1320.6901.5360.169
    Sod1Superoxide dismutase 1 solubleBC00206615,483.30.9420.7120.9710.911
    Sod2Superoxide dismutase 2 mitochondrial*NM_0136714,534.31.3050.1751.1950.461
    Sod3Superoxide dismutase 3 extracellularNM_0114355,812.80.7290.1470.6160.088
    Txn1Thioredoxin 1NM_0116605,8060.9250.5441.0640.623
    Txn2Thioredoxin 2NM_0199131,6760.9010.2080.9990.992
    Txndc1Thioredoxin domain containing 1NM_0283392,152.50.8780.4011.0000.999
    Txndc5Thioredoxin domain containing 5NM_1453672,078.10.9710.8361.0170.924
    TxnipThioredoxin interacting proteinNM_0237191,257.51.2930.3971.5130.240
    Txnrd1Thioredoxin reductase 1NM_0157622,784.40.9390.7140.9630.851
    Txnrd2Thioredoxin reductase 2NM_013711633.60.8270.4160.8580.472
    Txnrd3Thioredoxin reductase 3NM_153162148.40.9880.9441.1060.571
    TxnlThioredoxin-likeNM_0167923040.7650.0710.8130.051
    Txnl2Thioredoxin-like 2NM_0231402,667.91.0010.9961.1610.483
    Tnfaip6Tumor necrosis factor α–induced protein 6NM_009398121.41.3050.4331.1790.632
    Tnfaip1Tumor necrosis factor α–induced protein 1NM_0093953,090.20.9340.5681.0580.534
    Tnfaip2Tumor necrosis factor α–induced protein 2NM_0093965901.140.4160.9050.590
    Tnfaip3Tumor necrosis factor α–induced protein 3*NM_009397117.610.6120.00000525.9170.00014460
NOD
    AatfApoptosis antagonizing transcription factorNM_0198161,130.100.8420.1990.9850.914
    AvenApoptosis caspase activation inhibitorNM_028844145.301.3640.4311.3040.493
    Birc1aBaculoviral IAP repeat-containing 1aNM_008670375.800.6430.3650.7890.628
    Birc1bBaculoviral IAP repeat-containing 1bNM_0108721,020.500.8130.4370.8750.593
    Birc1eBaculoviral IAP repeat-containing 1eNM_010870314.000.6960.0750.9360.678
    Birc1fBaculoviral IAP repeat-containing 1fNM_010871933.100.6660.0940.8410.350
    Birc2Baculoviral IAP repeat-containing 2*NM_0074651,067.401.2630.0241.2550.004
    Birc3Baculoviral IAP repeat-containing 3*NM_007464429.903.7420.0132.6950.039
    Birc4Baculoviral IAP repeat-containing 4*NM_009688350.200.6920.1030.7950.201
    Birc5Baculoviral IAP repeat-containing 5NM_0096891,555.300.7360.1760.9870.947
    Birc6Baculoviral IAP repeat-containing 6NM_007566945.701.4270.3811.3440.447
    Bcl2B-cell leukemia/lymphoma 2*NM_009741183.000.8890.3041.0520.647
    Bcl2a1aB-cell leukemia/lymphoma 2–related protein A1a*NM_009742519.601.6390.4881.3230.720
    Bcl2a1cB-cell leukemia/lymphoma 2–related protein A1cNM_007535689.801.7330.1721.4160.436
    Bcl2a1dB-cell leukemia/lymphoma 2–related protein A1dNM_007536450.601.7030.4951.3400.731
    Bcl3B-cell leukemia/lymphoma 3NM_033601933.901.5480.1521.4790.215
    Bag4BCL2-associated athanogene 4NM_026121238.500.8440.1870.9920.931
    Bcl2lBcl2-like*NM_009743334.900.9510.7880.9010.606
    Bcl2l10Bcl2-like 10NM_0134791,782.800.6240.1390.7770.408
    Bcl2l2Bcl2-like 2NM_0075371,340.400.9380.7411.0380.838
    BfarBifunctional apoptosis regulatorNM_0259761,541.900.7080.0760.8440.304
    Dad1Defender against cell death 1NM_01001512,015.200.9470.4170.9930.926
    Gpx1Glutathione peroxidase 1NM_0081602,953.101.5860.0661.6310.053
    Gpx2Glutathione peroxidase 2NM_0306772,011.400.7020.0760.8290.191
    Gpx4Glutathione peroxidase 4NM_0081624,327.801.1710.6571.2950.477
    Gpx5Glutathione peroxidase 5NM_0103434,482.000.5730.0420.7990.314
    Hras1Harvey rat sarcoma virus oncogene 1NM_0082842,310.700.7810.0670.9120.400
    Hspa5Heat shock 70 kD protein 5 (glucose-regulated protein)*NM_02231011,382.501.4430.5781.2420.737
    Hspe1Heat shock protein 1 (chaperonin 10)NM_0083033,376.701.3950.5041.4730.441
    Hspd1Heat shock protein 1 (chaperonin)NM_0104772,855.001.0990.4701.2410.198
    HspcaHeat shock protein 1 αNM_0104807,447.901.4950.1871.3770.284
    HspcbHeat shock protein 1 βNM_00830211,423.101.0700.4541.0700.404
    Hsp105Heat shock protein 105NM_0135592,676.501.2420.2871.1550.460
    Hspa12bHeat shock protein 12BNM_028306370.900.8170.1880.9030.470
    Hspa1aHeat shock protein 1AAW763765329.201.3080.6431.1720.785
    Hspa1bHeat shock protein 1BM125733,062.500.9380.8801.0190.957
    Hspa1lHeat shock protein 1-likeNM_013558442.300.6800.0470.7940.075
    Hspa2Heat shock protein 2NM_008301355.401.3910.2271.4430.170
    Hspb3Heat shock protein 3NM_019960466.300.6520.1110.7580.131
    Hspa4Heat shock protein 4NM_0083002,247.701.3020.3151.3610.241
    Hspa8Heat shock protein 8NM_0311659,660.001.4860.2841.4790.297
    Hspb7Heat shock protein family member 7 (cardiovascular)NM_0138681,487.300.6630.4610.7860.647
    Hebp2Heme binding protein 2NM_0194872,048.900.7450.2590.8180.428
    Hmox1Heme oxygenase (decycling) 1*NM_0104425,759.000.7990.3590.8940.609
    Hmox2Heme oxygenase (decycling) 2NM_0104431,226.501.1740.4861.2670.304
    Hnf4Hepatic nuclear factor 4NM_008261687.501.1460.6111.2200.467
    Sod1Superoxide dismutase 1 solubleBM240246277.200.6300.1040.7570.177
    Sod1Superoxide dismutase 1 solubleBC00206619,857.701.0820.3191.1490.071
    Sod2Superoxide dismutase 2 mitochondrial*NM_0136715,852.101.2000.2901.0520.802
    Sod3Superoxide dismutase 3 extracellularNM_0114354,550.400.6770.0110.7120.031
    Txn1Thioredoxin 1NM_0116606,255.901.1020.3891.1640.113
    Txn2Thioredoxin 2NM_0199131,779.300.9570.7311.0150.911
    Txndc1Thioredoxin domain containing 1NM_0283392,646.101.0930.5641.1340.429
    Txndc5Thioredoxin domain containing 5NM_1453671,720.001.1540.3531.2670.120
    TxnipThioredoxin interacting proteinNM_023719928.302.0140.0051.3950.156
    Txnrd1Thioredoxin reductase 1NM_0157621,685.201.5500.2341.5380.239
    Txnrd2Thioredoxin reductase 2NM_013711601.000.6410.1580.7640.342
    Txnrd3Thioredoxin reductase 3NM_153162116.601.1750.2581.3740.093
    TxnlThioredoxin-likeNM_016792327.601.0050.9701.0190.900
    Txnl2Thioredoxin-like 2NM_0231402,450.001.3200.4381.2990.451
    Tnfaip6Tumor necrosis factor α–induced protein 6NM_009398142.001.2590.5901.1510.716
    Tnfaip1Tumor necrosis factor α–induced protein 1NM_0093953,049.801.0710.6251.0670.630
    Tnfaip2Tumor necrosis factor α–induced protein 2NM_009396561.501.0480.9250.9280.878
    Tnfaip3Tumor necrosis factor α–induced protein 3*NM_009397248.708.8840.0193.6100.115
  • * Genes validated by PCR and/or Western blot.