TABLE 1

Allele frequencies and results of association analysis in Amish subjects with type 2 diabetes, IGT, and NGT* for SNPs in TCF7L2

SNP nameChromosome locationMajor/minor alleleMinor allele frequencyType 2 diabetes vs. NGTIGT vs. NGTType 2 diabetes + IGT vs. NGT
Diabetes (n = 137)IGT (n = 139)NGT (n = 342)PORPORPOR
rs7901695114418675T/C0.400.350.280.051.510.061.460.011.53
rs7903146114422936C/T0.380.360.290.071.460.031.550.0081.57
rs11196205114471634C/G0.410.400.460.360.830.050.690.070.74
rs12255372114473489G/T0.420.410.370.111.380.121.360.041.40
  • * NGT control group restricted to subjects aged ≥38 years to avoid misclassification given the age-dependent penetrance of type 2 diabetes.

  • P values are based on genotyped frequencies, and ORs reflect the odds of disease associated with having two copies of the minor allele versus the odds of disease associated with having two copies of the major allele. The analysis models were adjusted for age, sex, and pedigree structure. Reported P values were derived using the additive model and were not adjusted for multiple comparisons.

  • P < 0.05.