TABLE 2

Mean fasting glucose, fasting insulin, glucose and insulin area under the OGTT curve, insulin secretion index, and homeostatis model assessment of insulin resistance by genotype in nondiabetic Amish subjects (n = 698) for each TCF7L2 SNP

Mean trait value ± SE*P
rs7901695TTCTCC
    n32130458
    Fasting glucose (mmol/l)5.11 ± 0.075.13 ± 0.065.04 ± 0.070.92
    ln(fasting insulin) (mmol/l)4.10 ± 0.064.10 ± 0.064.09 ± 0.060.92
    GAUC18.96 ± 0.5219.23 ± 0.5119.30 ± 0.530.82
    IAUC660.2 ± 66.7630.7 ± 66.0612.1 ± 67.20.36
    √IS0.81 ± 0.040.76 ± 0.040.77 ± 0.090.69
    HOMA-IR2.79 ± 0.222.69 ± 0.212.59 ± 0.220.27
rs7903146TTCTCC
    n30430060
    Fasting glucose (mmol/l)5.10 ± 0.045.13 ± 0.045.03 ± 0.070.92
    ln(fasting insulin) (mmol/l)4.11 ± 0.034.09 ± 0.034.12 ± 0.060.92
    GAUC18.81 ± 0.3218.99 ± 0.3018.96 ± 0.510.28
    IAUC665.2 ± 41.0637.7 ± 39.3630.3 ± 66.40.54
    √IS0.82 ± 0.040.77 ± 0.040.78 ± 0.090.39
    HOMA-IR2.81 ± 0.132.64 ± 0.122.78 ± 0.210.70
rs11196205GGCGCC
    n127341193
    Fasting glucose (mmol/l)5.09 ± 0.065.13 ± 0.045.07 ± 0.050.92
    ln(fasting insulin) (mmol/l)4.10 ± 0.054.09 ± 0.044.09 ± 0.040.92
    GAUC18.82 ± 0.4319.14 ± 0.3319.31 ± 0.370.27
    IAUC651.7 ± 55.3661.3 ± 43.5614.8 ± 46.80.44
    √IS0.76 ± 0.080.81 ± 0.040.76 ± 0.050.08
    HOMA-IR2.72 ± 0.182.72 ± 0.142.81 ± 0.150.92
rs12255372GGGTTT
    n24032992
    Fasting glucose (mmol/l)5.13 ± 0.055.13 ± 0.044.98 ± 0.060.06
    ln(fasting insulin) (mmol/l)4.11 ± 0.044.07 ± 0.034.14 ± 0.050.92
    GAUC19.12 ± 0.3519.13 ± 0.3118.88 ± 0.460.92
    IAUC701.0 ± 45.0631.1 ± 40.9634.0 ± 60.30.13
    √IS0.81 ± 0.050.76 ± 0.030.76 ± 0.080.57
    HOMA-IR2.79 ± 0.142.75 ± 0.132.72 ± 0.190.92
  • * Adjusted for age, sex, and family structure.

  • P values were derived using the additive model. GAUC, glucose area under the OGTT curve; HOMA-IR, homeostatis model assessment of insulin resistance; IAUC, insulin area under the OGTT curve; IS, insulin secretion.