TABLE 3

Association of the TCF7L2 rs12255372 (T/G) SNP with the risk of type 2 diabetes among U.S. Caucasian women and men

Genotype*CaseControlOR (95% CI)PPAR
Women
    n6871,051
    GG317 (46.1)564 (53.7)1.00
    GT290 (42.3)409 (38.8)1.25 (1.01–1.55)
    TT80 (11.6)78 (7.5)1.86 (1.30–2.67)
    Allele T450 (32.8)565 (26.8)1.32 (1.13–1.54)0.000214.8%
Men
    n886896
    GG373 (42.1)471 (52.6)1.00
    GT415 (46.8)363 (40.5)1.63 (1.32–2.02)
    TT98 (11.1)62 (6.9)2.15 (1.48–3.13)
    Allele T611 (34.5)487 (27.1)1.53 (1.31–1.80)<0.000122.3%
    P for heterogeneity‡0.19
Women + men
    n1,5731,947
    GG690 (43.8)1,035 (53.2)1.00
    GT705 (45.0)772 (39.6)1.43 (1.23–1.66)
    TT178 (11.2)140 (7.2)1.99 (1.54–2.59)
    Allele T1,121 (33.7)1,052 (27.0)1.42 (1.27–1.59)<0.000118.7%
  • Data are n (%) unless otherwise indicated.

  • * Genotype distributions do not depart from Hardy-Weinberg equilibrium.

  • Allele-specific OR calculated assuming a multiplicative model adjusted for age, date of blood draw, fasting status, and BMI. ‡χ2 test of heterogeneity for the association in women and men.