TABLE 3

Mean Si, AIRg, and DI by genotype in non-Amish Caucasians for each TCF7L2 SNP

Mean trait value ± SE*Regression model P valueRegression model P value (BMI adjusted)Spearman rank correlation P value
rs7901695TTCTCC
    n29135
    Si (10−5 [min × pmol/l]−1)5.63 ± 0.454.22 ± 0.682.38 ± 1.050.0030.020.0005
    AIRg (pmol/l)474.1 ± 45.6576.0 ± 70.7242.4 ± 122.50.470.380.74
    DI (Si × AIRg)2,558 ± 2632,285 ± 399797 ± 6930.040.090.03
rs7903146CCCTTT
    n31134
    Si (10−5 [min × pmol/l]−1)5.62 ± 0.443.77 ± 0.712.67 ± 1.180.0050.030.002
    AIRg (pmol/l)510.9 ± 44.9496.3 ± 77.6244.6 ± 123.10.090.050.29
    DI (Si × AIRg)2,674 ± 2491,941 ± 422824 ± 6700.0070.020.006
rs11196205GGCGCC
    n142410
    Si (10−5 [min × pmol/l]−1)4.84 ± 0.665.41 ± 0.523.62 ± 0.780.330.720.28
    AIRg (pmol/l)452.3 ± 64.4556.3 ± 49.0343.0 ± 80.40.490.410.60
    DI (Si × AIRg)2,013 ± 3582,828 ± 2781,509 ± 4460.670.910.48
rs12255372GGGTTT
    n30153
    Si (10−5 [min × pmol/l]−1)5.55 ± 0.463.92 ± 0.672.83 ± 1.390.020.080.009
    AIRg (pmol/l)486.2 ± 47.5508.4 ± 73.3355.4 ± 146.90.630.480.96
    DI (Si × AIRg)2,474 ± 2662,300 ± 403948 ± 8100.130.260.09
  • * Adjusted for age and sex.

  • Analyses were adjusted for age and sex, and P values were derived using the additive model.

  • P ≤ 0.05.