TABLE 3

Comparison of allele frequencies for TCF7L2 in Finnish, Icelandic, Danish, and American (U.S.) samples

SNPRelative position*Risk alleleCase/control statusRisk allele frequencyP value for testing of heterogeneity of allele frequencies
FinnishIcelandicDanishU.S.With FinnsWithout Finns
rs7901695−54.814CControl0.220.300.280.301.2 × 10−80.48
Case0.250.390.350.40<1.0 × 10−100.15
rs7903146−50.553TControl0.180.300.270.28<1.0 × 10−100.27
Case0.220.390.360.40<1.0 × 10−100.21
rs7895340−7.377AControl0.430.460.430.470.060.35
Case0.450.520.520.531.9 × 10−60.90
rs11196205−1.855CControl0.430.470.440.480.0150.13
Case0.450.530.520.541.8 × 10−70.38
rs122553720TControl0.160.280.260.26<1.0 × 10−100.17
Case0.200.360.330.39<1.0 × 10−100.12
  • * Genomic position (in kilobytes) relative to rs12255372 (114,798,892 on chromosome 10 in NCBI Build 35).

  • From Grant et al. (2); see online appendix Table 3.