TABLE 4

Effect of number of risk alleles from PPARG, KCNJ11, and TCF7L2 on the odds of type 2 diabetes: comparison to the three risk allele category

Number of risk allelesProportion of Finnish sampleAssuming equal increase in OR for each additional risk allele*Allowing for unequal increase in OR for each additional risk allele
OROR95% CIP value
00.0050.500.460.10–2.000.30
10.050.630.690.46–1.020.06
20.250.800.840.66–1.060.13
30.381.001.00Ref.
40.241.261.301.02–1.660.03
50.061.591.701.13–2.560.01
60.012.002.900.78–10.80.11
  • * Based on a 1.26-fold increase in OR for each additional risk allele (determined from an additive model for the number of risk alleles).

  • Independent estimation of the OR for each risk allele count.