TABLE 1

Adipose sphingomyelin and ceramide

LeanCompositionob/obComposition
Sphingomyelin (SM)
    C14 SM96 ± 610.7850.5 ± 10.50.67
    C16 SM7,617 ± 164.561.875,720 ± 1,38075.35
    C18 SM1,140 ± 5559.26510 ± 576.72
    C18:1 SM230 ± 1161.87139 ± 261.83
    C20 SM679 ± 2245.52223 ± 37*2.94
    C20:1 SM203.5 ± 75.51.6576.25 ± 16.2*1.00
    C22:1 SM356.3 ± 1202.90125 ± 19*1.65
    C24 SM571 ± 1084.64200 ± 33*2.63
    C24:1 SM1,430 ± 5211.61547.5 ± 1087.21
Ceramide (Cer)
    C14Cer2.2 ± 0.60.694.8 ± 0.5*2.14
    C16 Cer178.6 ± 28.856.19124 ± 28.755.18
    C18 Cer32.0 ± 6.510.0723.3 ± 4.910.37
    C18:1 Cer11.25 ± 0.453.547.6 ± 1.23.38
    C20 Cer9.5 ± 4.30.0311.7 ± 0.15.21
    C24 Cer38 ± 6.511.9620.4 ± 2.9*9.08
    C24:1 Cer38.5 ± 2.212.1127.8 ± 3.7*12.37
    DHC167.8 ± 2.32.455.1 ± 0.652.27
  • Data are means ± SD (pmol/mg tissue protein) or percent (n = 4). For lean vs. ob/ob mice:

  • * P < 0.05;

  • P < 0.01.