TABLE 2

Plasma sphingomyelin and ceramide

LeanCompositionob/obComposition
Sphingomyelin (SM)
    C14 SM4.6 ± 1.11.0114.85 ± 1.25*1.91
    C16 SM239 ± 1652.29534 ± 16.5*69.00
    C18 SM12.35 ± 2.42.7023 ± 3.42.96
    C18:1 SM3.84 ± 1.80.8411.23 ± 2.81.45
    C20 SM6.33 ± 0.71.387.4 ± 0.20.95
    C20:1 SM2.75 ± 0.460.604.9 ± 0.050.63
    C22 SM52.7 ± 9.511.5325.25 ± 1.53.24
    C22:1 SM27 ± 3.25.9117.98 ± 0.082.31
    C24 SM29.22 ± 5.56.3924.3 ± 2.073.12
    C24:1 SM79.3 ± 12.217.35115.4 ± 13.5714.83
Ceramide (Cer)
    C16 Cer49.2 ± 18.37.49109.5 ± 1.57.63
    C18 Cer15 ± 4.52.28106 ± 2.07.38
    C20 Cer31 ± 4.04.7255 ± 183.83
    C24 Cer370 ± 7056.32740 ± 4051.55
    C24:1 Cer182.6 ± 2627.79416 ± 20*28.98
    DHC169.2 ± 6.11.409.1 ± 1.80.63
  • Data are means ± SD (pmol/ml × 102) or percent (n = 4). For lean vs. ob/ob mice:

  • * P < 0.01;

  • P < 0.05;

  • P < 0.001.