TABLE 3

Summary of variants fully typed in African-American case and control subjects

LocationMajor/minor alleleCase minor allele frequencyControl minor allele frequencyχ2P
−10473A/G0.3820.3870.0160.900
−8379208 + 214/X0.3260.3984.440.035
−8340C/T0.1660.1971.310.250
−6735T/C0.1780.1930.300.580
−5606A/G0.1980.2100.240.620
−643T/G0.1570.1750.560.450
838C/G0.0490.0712.250.130
4891C/T0.1730.1600.280.590
6557T/A0.3470.3022.270.130
7359C/G0.3160.3100.040.840
7580C/T0.0330.0624.060.044
10309C/G0.1570.1770.680.410
21683A/G0.1340.1722.920.088
32150A/G0.0470.0600.840.360
41684C/G0.0560.0570.010.930
41720C/T0.1490.1261.100.290
209180C/T0.3730.3830.120.730
  • Variants typed in African-American families are shown by location, as in Table 1 and Fig. 1. Major and minor alleles are switched in African Americans from Caucasian frequencies for some SNPs. Note that −8379 has been dichotomized for this table into 208- and 214-bp alleles versus all others. The actual distribution is shown in Fig. 3. χ2, the χ2 value for allelic association (1 df); P value, the P value from χ2 test.