TABLE 2

Genotype frequencies in the case-control sample groups studied

SNPGenotypeW2SPW2CW2TP*Combined Cases58BCHRC+Combined controls
rs4506565AA172 (31.8)569 (38.0)105 (33.2)741 (36.4)901 (45.5)231 (45.0)1,132 (45.4)
AT278 (51.5)716 (47.9)164 (51.9)994 (48.2)880 (44.5)227 (44.3)1,107 (44.4)
TT90 (16.7)211 (14.1)47 (14.9)301 (14.8)198 (10.0)55 (10.7)253 (10.2)
rs7903146CC192 (35.1)579 (39.8)112 (35.8)771 (38.5)932 (47.4)243 (47.7)1,175 (47.4)
CT274 (50.1)686 (47.2)158 (50.5)960 (48.0)867 (44.1)217 (42.5)1,084 (43.8)
TT81 (14.8)189 (13.0)43 (13.7)270 (13.5)167 (8.5)50 (9.8)217 (8.8)
rs12243326TT209 (38.3)637 (43.0)118 (37.3)846 (41.7)981 (49.7)256 (48.7)1,237 (49.5)
CT266 (48.7)669 (45.2)155 (49.1)935 (46.1)838 (42.5)217 (41.3)1,055 (42.2)
CC71 (13.0)175 (11.8)43 (13.6)246 (12.1)154 (7.8)53 (10.1)207 (8.3)
rs12255372GG208 (38.3)628 (42.5)117 (36.3)836 (41.4)969 (49.1)251 (48.6)1,220 (49.0)
TG266 (49.0)675 (45.7)162 (50.3)941 (46.5)842 (42.6)215 (41.7)1,057 (42.4)
TT69 (12.7)175 (11.8)43 (13.4)244 (12.1)164 (8.3)50 (9.7)214 (8.6)
  • Data are n (%).

  • * W2TP genotype counts refer to the 350 probands from British/Irish families only.

  • Combined cases excluding W2TP.