TABLE 3

Estimates of the genotype and allele RRs for TCF7L2 SNPs

SNPBaseline genotypeRR (95% CI) for heterozygote*PRR (95% CI) for rare homozygote*PAllele RR (95% CI)P
rs4506565AA1.37 (1.21–1.56)9.4 × 10−71.82 (1.49–2.21)9.0 × 10−101.35 (1.23–1.47)1.6 × 10−11
rs7903146CC1.35 (1.19–1.53)3.1 × 10−61.90 (1.54–2.33)3.6 × 10−101.36 (1.24–1.48)1.3 × 10−11
rs12243326TT1.30 (1.14–1.47)4.6 × 10−51.74 (1.41–2.14)1.2 × 10−71.31 (1.19–1.43)4.3 × 10−9
rs12255372GG1.30 (1.15–1.47)3.9 × 10−51.66 (1.35–2.05)1.1 × 10−61.29 (1.18–1.41)2.2 × 10−8
  • Pvalues are exact. These results are based on the data presented in Table 2 and compares type 2 diabetes case (W2SP and W2C but not W2TP) and control (from the British Birth Cohort of 1958 and the Human Random Control resources) subjects.

  • * Genotype RRs compared with the baseline (common homozygote) genotype defined in the second column;

  • rs7903146: genotype RR for comparison of heterozygote and rare homozygote 1.41 (95% CI 1.15–1.72), P = 8.6 × 10−4.