TABLE 3

Activity of enzymes of fatty acid utilization and oxidative capacity in rodent models of insulin resistance

Wistar ratsZucker ratsdb/db mice
Standard dietFat+/+fa/fadb/+db/db
Citrate synthase23.4 ± 1.126.7 ± 1.2*27.5 ± 3.137.3 ± 1.4*25.4 ± 0.629.6 ± 1.3*
βHAD2.16 ± 0.102.74 ± 0.24*4.41 ± 0.356.18 ± 0.153.61 ± 0.194.54 ± 0.29
MCAD1.34 ± 0.071.64 ± 0.08*0.55 ± 0.060.73 ± 0.02*0.28 ± 0.020.41 ± 0.02
  • Data are means ± SE of 5–7 animals per group. Activities are expressed as units per gram wet weight.

  • * P < 0.05;

  • P < 0.01 vs. control group.