Activity of enzymes of fatty acid utilization and oxidative capacity in rodent models of insulin resistance
| Wistar rats | Zucker rats | db/db mice | ||||
|---|---|---|---|---|---|---|
| Standard diet | Fat | +/+ | fa/fa | db/+ | db/db | |
| Citrate synthase | 23.4 ± 1.1 | 26.7 ± 1.2* | 27.5 ± 3.1 | 37.3 ± 1.4* | 25.4 ± 0.6 | 29.6 ± 1.3* |
| βHAD | 2.16 ± 0.10 | 2.74 ± 0.24* | 4.41 ± 0.35 | 6.18 ± 0.15† | 3.61 ± 0.19 | 4.54 ± 0.29† |
| MCAD | 1.34 ± 0.07 | 1.64 ± 0.08* | 0.55 ± 0.06 | 0.73 ± 0.02* | 0.28 ± 0.02 | 0.41 ± 0.02† |
Data are means ± SE of 5–7 animals per group. Activities are expressed as units per gram wet weight.
* P < 0.05;
† P < 0.01 vs. control group.