TABLE 2

Effect of the weight loss and physical activity intervention on glucose metabolism and insulin sensitivity

BaselinePostinterventionP
Insulin-stimulated conditions
    Plasma glucose (mg/dl)95.0 ± 3.095.0 ± 2.0
    Plasma insulin (μU/ml)80 ± 4.088.0 ± 3.0
    Plasma free fatty acids (mmol/l)0.16 ± 0.020.09 ± 0.01<0.01
    Glucose disposal (mg · min−1 kg lbm−1)4.06 ± 0.616.27 ± 0.86<0.05
    EGP (mg · min−1 kg lbm−1)1.31 ± 0.280.61 ± 0.20<0.05
    Inhibition of EGP (%)64.0 ± 8.083.0 ± 6.0<0.05
    Resting metabolic rate (kJ/day)8,044.0 ± 554.07,809.0 ± 444.0
    Glucose oxidation (mg · min−1 kg lbm−1)2.63 ± 0.233.56 ± 0.17<0.001
    Fat oxidation (mg · min−1 kg lbm−1)0.92 ± 0.100.56 ± 0.10<0.001
Fasting conditions
    EGP (mg · min−1 kg lbm−1)3.62 ± 0.123.38 ± 0.16
    Resting metabolic rate (kJ/day)8,146.0 ± 594.07,624.0 ± 418.0
    Glucose oxidation (mg · min−1 kg lbm−1)1.70 ± 0.161.76 ± 0.18
    Fat oxidation (mg · min−1 kg lbm−1)1.33 ± 0.101.19 ± 0.09
  • Data are means ± SEM unless otherwise indicated. EGP, endogenous glucose production; lbm, lean body mass.