TABLE 4

Relationship between IENF and CNF morphology and measures of neuropathic severity

IENFD (no/mm)IENFBD (no/mm2)IENFL (μm)CNFD (no/mm2)CNFBD (no/mm2)CNFL (mm/mm2)
NDS (0–10)−0.425−0.376−0.343−0.299−0.107−0.088
0.0010.0060.0120.028NSNS
SNOL (ms)0.0110.0920.086−0.0030.4590.056
NSNSNSNS0.002NS
SNAP (μV)0.3510.3940.2950.176−0.114−0.018
0.0150.0070.047NSNSNS
SNCV (m/s)0.2460.2860.3330.176−0.0750.083
NS0.0540.024NSNSNS
PNOL (ms)−0.147−0.340−0.259−0.0350.072−0.070
NS0.018NSNSNSNS
PNAP (mV)0.2420.2190.3150.084−0.072−0.070
NSNS0.027NSNSNS
PNCV (m/s)0.4060.3910.5110.250−0.2000.181
0.0030.005<0.001NSNSNS
PNFL (ms)−0.364−0.160−0.0290.0160.272−0.130
0.032NSNSNSNSNS
TNOL (ms)−0.406−0.324−0.242−0.1440.130−0.001
0.0040.025NSNSNSNS
TNAP (mV)0.2020.2690.1960.2590.0270.219
NSNSNSNSNSNS
TNCV (m/s)0.3700.2250.2210.127−0.2360.193
0.014NSNSNSNSNS
TNFL (ms)−0.589−0.473−0.128−0.0350.313−0.017
< 0.0010.005NSNSNSNS
CDT (percentile)−0.466−0.408−0.285−0.399−0.025−0.081
< 0.0010.0030.0410.003NSNS
HP-VAS 0.5 (percentile)−0.311−0.297−0.223−0.291−0.269−0.134
0.0280.039NS0.040NSNS
HP-VAS 5.0 (percentile)−0.357−0.220−0.146−0.264−0.267−0.221
0.010NSNSNSNSNS
HP-VAS 0.5–5.0 (percentile)0.0090.2550.1480.0320.029−0.069
NSNSNSNSNSNS
DB-HRV (percentile)0.2680.2040.1480.3480.0730.202
NSNSNS0.024NSNS
  • Data are Spearman correlations (rs) and significance (P) between intraepidermal and corneal nerve morphology and NDS, electrophysiology, and quantitative sensory tests. Significant correlations are in bold type.