TABLE 3

Effects of the weight loss and physical activity intervention on skeletal muscle mitochondrial content and functional capacity

BaselinePostinterventionP
Electron microscopy
    Mitochondrial density (%)3.69 ± 0.405.74 ± 0.51<0.001
    Mean mitochondrial size (μm2)0.062 ± 0.0040.084 ± 0.008<0.05
Biochemistry
    Cardiolipin (μg/mU CK)58.8 ± 5.487.3 ± 8.8<0.01
    mtDNA copy number (mtDNA/nDNA)2,114.0 ± 156.02,591.0 ± 320.00.05
    Citrate synthase (unit/mU CK)3.28 ± 0.495.12 ± 0.90<0.05
    NADH oxidase (unit/mU CK)0.16 ± 0.030.27 ± 0.06<0.05
Muscle fiber type (%)
    Type I47.0 ± 2.050.0 ± 1.0
    Type IIa42.0 ± 1.037.0 ± 1.0
    Type IIb11.0 ± 1.013.0 ± 1.0
  • Data are means ± SEM unless otherwise indicated. CK, creatine kinase.