TABLE 1

Metabolic characteristics of the animals

Wild typeNormo-glycemic L1Diabetic L1
Body weight (g)25.6 ± 0.924.9 ± 0.929.3 ± 1.2*
Fat mass (g)4.8 ± 0.55.1 ± 0.45.6 ± 0.6
Fat-free mass (g)20.7 ± 1.119.8 ± 0.723.7 ± 1.2
Glucose (mg/dl)160 ± 9154 ± 8240 ± 23*
FFA (mEq/l)0.20 ± 0.040.37 ± 0.06*0.33 ± 0.06
Triglycerides (mg/ml)0.10 ± 0.040.24 ± 0.04*0.24 ± 0.06*
β-OH butyrate (mmol/l)1.31 ± 0.152.29 ± 0.38*ND
Insulin (ng/ml)1.0 ± 0.312.3 ± 2.1§19.3 ± 3.5§
Adiponectin (μg/ml)8.5 ± 1.621.2 ± 3.1§15.4 ± 2.1*
Resistin (ng/ml)3.3 ± 0.44.1 ± 0.53.1 ± 0.4
  • Data are means ± SE. β-OH butyrate was measured after a 16-h fast. All other measurements were made in 3-month-old fed male mice.

  • * P < 0.05 vs. wild type;

  • § P < 0.01 vs. wild type;

  • P < 0.05 vs. normoglycemic L1;

  • P < 0.01 vs. normoglycemic L1. FFA, free fatty acid; ND, not determined.