TABLE 2

Single-marker univariate and multivariate Cox proportional hazards analysis of VEGFA SNPs with severe retinopathy

MarkerMinor allele (%)StrandSample sizeUnivariateMultivariate
HR95% CIPHR95% CIP
rs1547651T (16.4)Forward1,3531.120.87–1.430.381.020.78–1.320.89
rs699947A (49.5)Forward1,3440.900.75–1.070.230.830.69–1.000.045
rs2010963G (31.8)Reverse1,3131.130.93–1.370.221.210.98–1.500.078
rs3024987A (12.6)Reverse1,3621.040.81–1.330.781.050.81–1.360.72
rs833068A (32.4)Forward1,3311.100.90–1.330.361.200.97–1.480.093
rs833070A (49.7)Forward1,3290.880.74–1.050.160.820.68–1.000.045
rs3024994A (4.9)Reverse1,3621.120.75–1.660.581.220.80–1.850.36
rs2146323A (35.7)Forward1,3620.890.74–1.080.230.770.63–0.940.011
rs3025007A (44.0)Reverse1,3580.800.67–0.960.0170.800.66–0.960.017
rs3025010C (37.8)Forward1,3400.870.72–1.050.130.750.62–0.920.0052
rs3025020T (32.0)Reverse1,3610.820.67–0.990.0390.750.61–0.920.0051
rs3025021T (32.3)Forward1,3411.190.98–1.430.0731.371.13–1.660.0017
rs3025028G (43.4)Reverse1,3661.100.92–1.320.291.241.03–1.490.026
rs3025030G (13.3)Reverse1,3071.060.81–1.400.661.060.80–1.420.67
rs3025035A (7.2)Reverse1,3621.361.01–1.850.0441.230.88–1.710.22
rs3025053A (11.0)Forward1,3621.050.79–1.390.761.060.79–1.440.69
  • The results are shown for the available genotype dataset for each marker using an additive mode, with the major allele frequency (i.e., common homozygote) used as the reference. Results of the same analysis for the common dataset (1,180 individuals) are provided in online appendix Tables 9 and 12. The covariates included are listed in the online appendix supplementary text (and Table 3 for the multivariate model).