Single-marker univariate and multivariate Cox proportional hazards analysis of VEGFA SNPs with severe retinopathy
| Marker | Minor allele (%) | Strand | Sample size | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||||
| rs1547651 | T (16.4) | Forward | 1,353 | 1.12 | 0.87–1.43 | 0.38 | 1.02 | 0.78–1.32 | 0.89 |
| rs699947 | A (49.5) | Forward | 1,344 | 0.90 | 0.75–1.07 | 0.23 | 0.83 | 0.69–1.00 | 0.045 |
| rs2010963 | G (31.8) | Reverse | 1,313 | 1.13 | 0.93–1.37 | 0.22 | 1.21 | 0.98–1.50 | 0.078 |
| rs3024987 | A (12.6) | Reverse | 1,362 | 1.04 | 0.81–1.33 | 0.78 | 1.05 | 0.81–1.36 | 0.72 |
| rs833068 | A (32.4) | Forward | 1,331 | 1.10 | 0.90–1.33 | 0.36 | 1.20 | 0.97–1.48 | 0.093 |
| rs833070 | A (49.7) | Forward | 1,329 | 0.88 | 0.74–1.05 | 0.16 | 0.82 | 0.68–1.00 | 0.045 |
| rs3024994 | A (4.9) | Reverse | 1,362 | 1.12 | 0.75–1.66 | 0.58 | 1.22 | 0.80–1.85 | 0.36 |
| rs2146323 | A (35.7) | Forward | 1,362 | 0.89 | 0.74–1.08 | 0.23 | 0.77 | 0.63–0.94 | 0.011 |
| rs3025007 | A (44.0) | Reverse | 1,358 | 0.80 | 0.67–0.96 | 0.017 | 0.80 | 0.66–0.96 | 0.017 |
| rs3025010 | C (37.8) | Forward | 1,340 | 0.87 | 0.72–1.05 | 0.13 | 0.75 | 0.62–0.92 | 0.0052 |
| rs3025020 | T (32.0) | Reverse | 1,361 | 0.82 | 0.67–0.99 | 0.039 | 0.75 | 0.61–0.92 | 0.0051 |
| rs3025021 | T (32.3) | Forward | 1,341 | 1.19 | 0.98–1.43 | 0.073 | 1.37 | 1.13–1.66 | 0.0017 |
| rs3025028 | G (43.4) | Reverse | 1,366 | 1.10 | 0.92–1.32 | 0.29 | 1.24 | 1.03–1.49 | 0.026 |
| rs3025030 | G (13.3) | Reverse | 1,307 | 1.06 | 0.81–1.40 | 0.66 | 1.06 | 0.80–1.42 | 0.67 |
| rs3025035 | A (7.2) | Reverse | 1,362 | 1.36 | 1.01–1.85 | 0.044 | 1.23 | 0.88–1.71 | 0.22 |
| rs3025053 | A (11.0) | Forward | 1,362 | 1.05 | 0.79–1.39 | 0.76 | 1.06 | 0.79–1.44 | 0.69 |
The results are shown for the available genotype dataset for each marker using an additive mode, with the major allele frequency (i.e., common homozygote) used as the reference. Results of the same analysis for the common dataset (1,180 individuals) are provided in online appendix Tables 9 and 12. The covariates included are listed in the online appendix supplementary text (and Table 3 for the multivariate model).