TABLE 4

Family-based association analyses between VEGFA markers and Martingale residuals from the Cox proportional hazards model of severe retinopathy via FBAT version 1.70.3 software, assuming an additive model of inheritance

Marker(s)Allele (frequency)Number of informative familiesZ statisticP
Single-marker analyses
    rs1547651T (0.182)2910.660.51
    rs699947C (0.502)4412.190.029
    rs3025010T (0.614)4271.320.19
    rs3025021T (0.33)5482.490.013
Multimarker analyses*
    1A-C (0.372)435−2.0520.040
    2C-C (0.321)4210.0670.94
    3C-T (0.184)3282.0980.035
    4A-T (0.123)2510.2860.77
  • * Haplotype analyses of rs699947 and rs3025021. For multimarker analysis, four-marker test of rs1547651, rs699947, rs3025010, and rs3025021: S_MM = 12.30; 4 d.f.; P = 0.015; two-marker test of rs699947 and rs3025021: S_MM = 9.97; 2 d.f.; P = 0.0068.