TABLE 3

Logistic regression analysis with treatment failure as the dependent variable

rs1225372rs7903146
Without baseline A1CWith baseline A1CWithout baseline A1CWith baseline A1C
OR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)P
Sulfonylurea (n)901579901579
    GT1.06 (0.79–1.43)0.691.14 (0.78–1.68)0.50CT1.13 (0.84–1.52)0.421.23 (0.84–1.81)0.29
    TT1.94 (1.23–3.06)0.0052.16 (1.21–3.86)0.009TT1.73 (1.11–2.70)0.0151.90 (1.09–3.33)0.024
    Sex (male = 1; female = 0)0.68 (0.51–0.90)0.0080.60 (0.41–0.87)0.0070.68 (0.51–0.91)0.0090.60 (0.42–0.87)0.007
    Age diagnosed (years)0.99 (0.98–1.01)0.300.99 (0.97–1.00)0.130.99 (0.98–1.01)0.340.99 (0.97–1.00)0.15
    Dose (per 5% of maximum)1.20 (1.14–1.27)<0.0011.18 (1.10–1.27)<0.0011.21 (1.14–1.27)<0.0011.18 (1.11–1.27)<0.001
    Adherence (per 5%)1.06 (1.02–1.11)0.0031.04 (0.99–1.10)0.131.07 (1.02–1.11)0.0011.05 (0.99–1.11)0.12
    A1C pretreatment (%)——1.38 (1.24–1.52)<0.001——1.30 (1.18–1.44)<0.001
Metformin (n)945755945755
    GT1.06 (0.80–1.39)0.700.96 (0.70–1.33)0.81CT1.26 (0.95–1.67)0.101.17 (0.85–1.61)0.34
    TT1.41 (0.89–2.25)0.151.09 (0.63–1.91)0.75TT1.58 (1.01–2.50)0.0471.19 (0.69–2.02)0.53
    Sex (male = 1; female = 0)0.98 (0.75–1.29)0.911.10 (0.81–1.49)0.540.98 (0.75–1.28)0.891.09 (0.81–1.48)0.57
    Age diagnosed (years)0.99 (0.98–1.01)0.320.99 (0.97–1.01)0.190.99 (0.98–1.01)0.390.99 (0.97–1.01)0.23
    BMI average (kg/m2)1.01 (0.98–1.03)0.841.00 (0.97–1.01)0.911.01 (0.98–1.03)0.591.00 (0.98–1.03)0.82
    Dose (per 5% of maximum)1.29 (1.19–1.41)<0.0011.31 (1.18–1.45)<0.0011.29 (1.19–1.41)<0.0011.31 (1.17–1.45)<0.001
    Adherence (per 5%)1.01 (0.95–1.06)0.840.98 (0.92–1.04)0.561.00 (0.95–1.06)0.910.98 (0.92–1.04)0.51
    A1C pretreatment——1.38 (1.24–1.52)<0.001——1.38 (1.24–1.53)<0.001

  • P < 0.05 are bold.