Table 2

Established amino acids markers and incident diabetes during the DPP

Without adjustmentWith adjustment
Sample NWeighted NHR (95% CI)PHR (95% CI)P
Isoleucine7413,1801.24 (1.03, 1.50)0.031.14 (0.95, 1.36)0.15
Leucine7403,1791.27 (1.05, 1.53)0.011.15 (0.97, 1.37)0.11
Valine7413,1801.22 (1.02, 1.47)0.031.13 (0.96, 1.34)0.14
Phenylalanine7413,1801.03 (0.89, 1.19)0.690.98 (0.85, 1.12)0.72
Tyrosine7413,1801.16 (1.02, 1.33)0.031.09 (0.93, 1.27)0.25
Glutamine/glutamate7413,1800.82 (0.72, 0.93)0.0020.88 (0.74, 1.04)0.13
  • HR is diabetes risk for each SD increase in log metabolite level. Model results are shown without and with adjustment for age, sex, BMI, FPG, hypertension (yes/no), race/ethnicity, and treatment group. Sample N indicates number of measured values and weighted N indicates number of samples included in the IPW cohort. Results are from the IPW cohort.