Table 2

Relative expression of genes related to glucose uptake and lipid metabolism in adipose tissue from IS and IR subjects at baseline and changes with weight gain

GeneIS baseline* (n = 10)IR baseline* (n = 10)P baselineIS ∆IR ∆P
Glut41.1 ± 0.520.62 ± 0.410.02−0.08 ± 0.330.47 ± 0.500.01
FABP41.08 ± 0.220.89 ± 0.280.08−0.21 ± 0.210.13 + 0.410.04
PEPCK1.00 ± 0.220.67 ± 0.240.003−0.18 ± 0.240.16 ± 0.370.01
ACC11.67 ± 1.11.13 ± 0.740.210.29 ± 0.990.49 ± 0.720.53
CD361.21 ± 0.401.08 ± 0.310.37−0.03 ± 0.460.08 ± 0.520.52
FATP11.00 ± 0.170.85 ± 0.220.06−0.14 ± 0.190.10 ± 0.360.08
LPL1.44 ± 0.551.22 ± 0.400.290.02 ± 0.610.23 ± 0.530.39
HSL1.35 ± 0.371.02 ± 0.350.049−0.19 ± 0.300.30 ± 0.560.03
ATGL1.47 ± 0.321.07 ± 0.290.01−0.30 ± 0.390.17 ± 0.260.006
  • *Baseline comparison adjusted for baseline %BF; change comparison adjusted for ∆%BF. Relative expression at peak weight was normalized to baseline expression for each gene and change calculated as the difference between peak weight and baseline relative expression;

  • Paired t test comparing peak weight to baseline P < 0.05;

  • Paired t test comparing peak weight to baseline P < 0.01.