TABLE 1

Diabetes complications: miRNAs and their targets

ComplicationKnown targetsReference
Diabetic nephropathy miR-21PTEN(29) unpublished*
 miR-29 familyCollagens(25) unpublished*
 miR-192ZEB2, Col 1(16,18,22,23)
 miR-93VEGF(34)
 miR-200 familyZEB1, ZEB2, TGF-β2(18,19)
 miR-216aYB-1, PTEN(15,26)
 miR-377PAK1, MnSOD(30)
Retinopathy
 miR-93, miR-200, and miR-29 families?VEGF(34) indirect
Atherosclerosis
 miR-16COX-2(39) indirect
 miR-503?CCNE1, cdc25A(40)
Heart
 miR-21SPRY1(50,51)
 miR-29Collagens(17)
 miR-30?CTGF(48) indirect
 miR-1/133ERG, RhoA, Cdc42, WHSC2, HCN1, and HCN4(4447)
 miR-320VEGF, FGF, IGF-1, and IGF-1R(46)
  • *H.Y.L., unpublished data.

  • †Inferred from the reference.