TABLE 1

Insulin (100 nmol/l)-induced IR autophosphorylation in the presence of either TLK16998 (50 μmol/l) or Merck L7 (50 μmol/l) in insulin-resistant cells.

Insulin (100 nmol/l)Insulin + L7 (50 μmol/l)Insulin + TLK16998 (50 μmol/l)
Control100 ± 13135 ± 7*165 ± 2*
TNF-α–treated50 ± 3164 ± 16*102 ± 1*
TPA-treated39 ± 552 ± 993 ± 24*
HTC-IR PCI43 ± 467 ± 3*71 ± 8*
  • Data are means ± SE of the percent of insulin-stimulated IR tyrosine phosphorylation of control (untreated cells).

  • *

    * Significant effect of the compound plus insulin over insulin alone in each cell line;

  • values significantly greater than those of insulin-stimulated control cells;

  • values significantly reduced compared with insulin-stimulated control cells (P < 0.05).