TABLE 3

Changes in circulating hormone concentrations and correlation of these changes with changes in insulin sensitivity

Subjects who remained at Tanner stage I
Subjects who became Tanner stage III or IV
Initial visitFollow-upInitial visitFollow-up
Estradiol (pg/ml)4.2 ± 0.05.0 ± 3.54.2 ± 0.013.2 ± 14.6*
Testosterone (ng/dl)11.8 ± 0.014.3 ± 12.013.4 ± 5.6112.4 ± 147.9*
Androstendione (ng/ml)0.49 ± 0.220.61 ± 0.40.65 ± 0.251.12 ± 0.55*
Cortisol (ug/dl)10.7 ± 3.310.6 ± 4.510.8 ± 3.110.0 ± 3.2
FSH (mIU/ml)0.79 ± 0.651.34 ± 1.37*1.32 ± 0.863.40 ± 1.87*
IGF-I (ng/ml)216.3 ± 84.1243.1 ± 97.3*273.0 ± 97.3472.6 ± 172.6*
Leptin (ng/ml)11.9 ± 9.113.2 ± 10.115.2 ± 14.317.1 ± 18.3
  • Data are means ± SD.

  • *

    * P < 0.05 for change over time by paired t test (note that the SD for estradiol and testosterone appears as zero in some cases because all values were equal to the minimal detectable level).