TABLE 2

Glucose infusion rates (mg · kg−1 · min−1) during hyperglycemic clamp experiments with the exogenous administration of GIP (30–90 min: 2 pmol · kg−1 · min−1)

Experimental periodHealthy control subjectsFirst-degree relatives of type 2 diabetic patientsType 2 diabetic patientsSignificance (P value, ANOVA)
0–15 min4.0 ± 0.43.9 ± 0.31.3 ± 0.4*<0.0001
15–30 min4.4 ± 0.64.0 ± 0.41.7 ± 0.7*0.0025
30–45 min4.2 ± 0.64.4 ± 0.41.3 ± 0.5*0.0004
45–60 min4.5 ± 0.55.3 ± 0.51.2 ± 0.5*<0.0001
60–75 min6.9 ± 0.96.9 ± 0.81.5 ± 0.5*<0.0001
75–90 min8.2 ± 1.07.8 ± 0.62.3 ± 0.6*<0.0001
90–105 min8.5 ± 1.58.2 ± 0.82.3 ± 0.6*0.0003
105–120 min8.2 ± 1.38.4 ± 0.91.7 ± 0.5*<0.0001
  • Data are means ± SE. P values were calculated by ANOVA with Duncan’s post hoc test to describe differences between the three groups of patients.

  • *

    * Significant difference (P < 0.05) versus healthy control subjects.