TABLE 2

Plasma glucose, insulin and FFA concentrations during the hyperinsulinemic-euglycemic clamp

Basal
Biopsy
End of clamp
FHFH+FHFH+FHFH+
Glucose (mg/dl)94 ± 194 ± 288 ± 291 ± 291 ± 292 ± 1
Insulin (μU/ml)7.0 ± 0.58.5 ± 0.5*56 ± 563 ± 356 ± 363 ± 3
FFA (μmol/l)733 ± 33687 ± 41NDND91 ± 1382 ± 14
  • Data are means ± SE. Plasma glucose, insulin, and FFA concentrations during the basal state (−30 to 0 min); during the first 30 min of the hyperinsulinemic-euglycemic clamp (10–30 min), at which time a percutaneous muscle biopsy was performed; and at the end of the euglycemic clamp (90–120 min), at which time rates of insulin-stimulated glucose disposal were determined.

  • *

    * P < 0.05 vs. FH group. ND, not done.