TABLE 1

Effects of starvation or activation of PPAR-α in vivo on plasma insulin and metabolite concentrations

ControlStarvation (48 h)WY14,643 treatment (24 h)
Insulin (μU/ml)32 ± 4 (14)11 ± 2* (9)26 ± 5 (9)
Glucose (mmol/l)8.8 ± 0.4 (8)5.2 ± 0.4* (8)8.5 ± 0.8 (6)
NEFA (mmol/l)0.32 ± 0.04 (9)1.56 ± 0.18* (9)0.35 ± 0.04 (6)
  • Data are means ± SE, with the numbers of rats in parentheses. Details of the protocols for starvation or treatment with WY14,643 are described in research design and methods. Plasma insulin, glucose, and NEFA concentrations in blood sampled from the chest cavity were determined using commercial kits.

  • *

    * P < 0.001 versus control (fed ad libitum).