TABLE 2

Plasma lipid, glucose, and insulin levels in mice with or without APOC1 overexpression

GenotypeCholesterol (mmol/l)Triglycerides (mmol/l)FFA (mmol/l)Glucose (mmol/l)Insulin (ng/ml)
Wild-type background
 Wild-type1.6 ± 0.10.2 ± 0.10.6 ± 0.39.5 ± 0.61.0 ± 0.4
 APOC17.0 ± 1.2*9.1 ± 2.3*1.1 ± 0.5*6.9 ± 0.8*1.1 ± 0.3
ob/ob background
ob/ob4.4 ± 0.30.4 ± 0.11.0 ± 0.417.9 ± 4.29.8 ± 2.0
ob/ob APOC110.9 ± 2.79.4 ± 6.11.7 ± 0.23.4 ± 1.51.5 ± 0.8
  • Data are means ± SD of at least seven mice per group. Male mice of the respective genotypes were compared at the age of 3 months. Plasma cholesterol, triglycerides, FFA, glucose, and insulin levels were measured after 4 h of fasting as described in research design and methods.

  • *

    * P < 0.05 versus wild-type mice;

  • P < 0.05 versus ob/ob mice.