TABLE 1

Effect of long-term high-fat feeding in wild-type and PPAR-α–null mice on two genetic backgrounds

C57BL/6N mice
Sv/129 mice
Wild-type
PPAR-α–null
Wild-type
PPAR-α–null
Standard diet (n = 6)High-fat diet (n = 6)Standard diet (n = 6)High-fat diet (n = 6)Standard diet (n = 8)High-fat diet (n = 8)Standard diet (n = 8)High-fat diet (n = 8)
Food intake (kcal · kg−1 · day−1)465 ± 28.5511 ± 15.2506 ± 21.0560 ± 28.9383 ± 7.35414 ± 13.3369 ± 11.6386 ± 22.4
Body weight (g)32.7 ± 0.9538.0 ± 1.3730.8 ± 0.9432.4 ± 0.7827.1 ± 0.8034.5 ± 1.2829.6 ± 0.7033.1 ± 0.90
Liver weight (g)1.46 ± 0.121.44 ± 0.101.50 ± 0.071.48 ± 0.111.00 ± 0.031.26 ± 0.051.26 ± 0.081.95 ± 0.10
Adiposity index* (%)1.60 ± 0.333.58 ± 0.341.71 ± 0.253.74 ± 0.402.94 ± 0.236.34 ± 0.783.42 ± 0.365.93 ± 0.52
Plasma glucose (mmol/l)9.8 ± 0.6711.5 ± 0.7510.6 ± 0.729.3 ± 0.429.6 ± 0.5611.6 ± 0.589.1 ± 0.418.2 ± 0.65
Plasma insulin (pmol/l)209 ± 21.3398 ± 50.1189 ± 31.8225 ± 30.2215 ± 23.9378 ± 38.8284 ± 26.9256 ± 32.3
  • Data are means ± SE. Mice on the C 57BL/6N genetic background were fed the high-fat diet for 16 weeks. Mice on the Sv/129 genetic background were fed the high-fat diet for 22 weeks.

  • *

    * Adiposity index was the ratio of epididymal adipose tissue to body weight for C57BL/6N mice and the ratio of epididymal + inguinal adipose tissue to body weight for Sv/129 mice.

  • P < 0.05 versus standard diet.