TABLE 2

Effect of high-fat feeding on IR index

Wild-type
PPAR-α–null
Standard diet (n = 5)High-fat diet (n = 5)Standard diet (n = 6)High-fat diet (n = 5)
AUC glucose (mg/dl · 2 h)115 ± 15296 ± 78*106 ± 16128 ± 27
AUC insulin (ng/dl · 2 h)17.3 ± 3.127.6 ± 2.7*23.2 ± 6.312.8 ± 2.5
IR Index (AUC glucose · AUC insulin)1,970 ± 4138,400 ± 2,790*2,490 ± 7301,680 ± 548
  • Data are means ± SE. Areas under the insulin and glucose curves were calculated from the data shown in Fig. 4. The IR index is the product of glucose and insulin AUCs.

  • *

    * P < 0.05 versus standard diet.