TABLE 2

Glucose infusion rate, endogenous glucose production, glucose disposal, and glycerol turnover data under basal state or during an isoglycemic clamp from lean and obese Zucker rats

		Lean			Obese
		Control	AICAR	Insulin	Control	AICAR	Insulin
Glucose infusion rates (μmol · kg⁻¹ · min⁻¹)	Clamp	NA	74.3 ± 10.7	82.4 ± 3.5	NA	21.0 ± 2.2*	24.0 ± 4.4*
Glucose disposal (μmol · kg⁻¹ · min⁻¹)	Clamp	40.5 ± 3.8	80.5 ± 5.7†	103.5 ± 15.8†	52.4 ± 4.2	46.4 ± 4.1*	45.7 ± 4.8*
Endogenous glucose production (μmol · kg⁻¹ · min⁻¹)	Basal	37.3 ± 3.2	35.3 ± 2.7	45.1 ± 3.2	49.4 ± 4.4*	52.7 ± 2.8*	48.4 ± 5.2*
Endogenous glucose production (μmol · kg⁻¹ · min⁻¹)	Clamp	40.5 ± 3.8	6.2 ± 1.9§†	21.1 ± 5.3§	53.3 ± 4.2	25.4 ± 2.3§†	21.7 ± 6.1§†
Glycerol turnover (μmol · kg⁻¹ · min⁻¹)	Basal	20.6 ± 4.6	16.1 ± 2.0	17.8 ± 5.0	15.2 ± 2.2	23.1 ± 4.5	19.7 ± 2.3
Glycerol turnover (μmol · kg⁻¹ · min⁻¹)	Clamp	16.4 ± 4.0	10.5 ± 1.9§	14.0 ± 4.6§	14.5 ± 1.4	13.2 ± 3.5§	18.2 ± 2.0

Data are means ± SE, n = 7–10 in each group. Rats were infused with isotonic saline (control), AICAR (bolus, 100 mg/kg body wt · constant, 10 mg · kg⁻¹ body wt · min⁻¹), or insulin (4 mU · kg⁻¹ · min⁻¹).
*
* Significantly different from lean littermates undergoing the same treatment (P < 0.01);
†
† significantly different from control group at same time interval (P < 0.01):
§
§ clamp value significantly different from basal (P < 0.05); NA, not applicable.