TABLE 2

Glucose infusion rate, endogenous glucose production, glucose disposal, and glycerol turnover data under basal state or during an isoglycemic clamp from lean and obese Zucker rats

Lean
Obese
ControlAICARInsulinControlAICARInsulin
Glucose infusion rates (μmol · kg−1 · min−1)ClampNA74.3 ± 10.782.4 ± 3.5NA21.0 ± 2.2*24.0 ± 4.4*
Glucose disposal (μmol · kg−1 · min−1)Clamp40.5 ± 3.880.5 ± 5.7103.5 ± 15.852.4 ± 4.246.4 ± 4.1*45.7 ± 4.8*
Endogenous glucose production (μmol · kg−1 · min−1)Basal37.3 ± 3.235.3 ± 2.745.1 ± 3.249.4 ± 4.4*52.7 ± 2.8*48.4 ± 5.2*
Clamp40.5 ± 3.86.2 ± 1.9§21.1 ± 5.3§53.3 ± 4.225.4 ± 2.3§21.7 ± 6.1§
Glycerol turnover (μmol · kg−1 · min−1)Basal20.6 ± 4.616.1 ± 2.017.8 ± 5.015.2 ± 2.223.1 ± 4.519.7 ± 2.3
Clamp16.4 ± 4.010.5 ± 1.9§14.0 ± 4.6§14.5 ± 1.413.2 ± 3.5§18.2 ± 2.0
  •  Data are means ± SE, n = 7–10 in each group. Rats were infused with isotonic saline (control), AICAR (bolus, 100 mg/kg body wt · constant, 10 mg · kg−1 body wt · min−1), or insulin (4 mU · kg−1 · min−1).

  • *

    * Significantly different from lean littermates undergoing the same treatment (P < 0.01);

  • significantly different from control group at same time interval (P < 0.01):

  • §

    § clamp value significantly different from basal (P < 0.05); NA, not applicable.