TABLE 1

Different indexes for insulin secretion from subjects without (Gly/Gly) and with (X/Arg) the Gly972Arg polymorphism in IRS-1

Gly/GlyX/ArgP
n18131
Estimated first phase1,134 ± 61872 ± 800.01
Estimated second phase298 ± 14239 ± 170.007
IAUC/GAUC45 ± 1036 ± 30.02
CPAUC/GAUC406 ± 10341 ± 190.002
CIR300.0090 ± 0.00090.0056 ± 0.00060.03
Insulinogenic index (I)0.43 ± 0.040.30 ± 0.030.03
Insulinogenic index (CP)2.28 ± 0.081.96 ± 0.200.05
  • Data are means ± SE. CIR was calculated as Ins30/(Gluc30 × (Glu30–70); the insulinogenic index for insulin was calculated as (Ins30–Ins0)/Gluc30 and analogously for C-peptide (see research design and methods for details).