TABLE 2

Effect of dietary CLA isomer supplementation on insulin signaling events in skeletal muscle

Treatment
Lean controlZDF controlc9,t1150:50Pair-fed
PI 3-kinase activity (% of lean basal)
 EDL
  Basal10091.5 ± 9.971.1 ± 12.174.0 ± 12.6101.0 ± 41.8
  Insulin348.0 ± 78.8158.0 ± 16.9118.1 ± 30.4127.0 ± 24.0208.6 ± 23.1
 Soleus
  Basal100170.0 ± 30.0194.0 ± 17.0141.0 ± 8.0125.0 ± 18.0
  Insulin519.0 ± 140.0307.2 ± 78.0283.0 ± 33.0270.0 ± 64.0234.0 ± 100
Phospho-Akt expression (% of lean basal)
 EDL
  Basal10036.1 ± 6.48*78.0 ± 23.670.3 ± 18.237.3 ± 6.0*
  Insulin881.4 ± 259.0428.6 ± 145.0466.5 ± 113.0504.0 ± 109.0456.5 ± 77.4
 Soleus
  Basal10053.2 ± 12.479.3 ± 28.367.2 ± 20.268.1 ± 28.6
  Insulin256.4 ± 70.4180.4 ± 46.3102.5 ± 24.0136.7 ± 36.0240.4 ± 40.4
  • Data are means ± SE.

  • *

    * P < 0.001 vs. lean control;

  • P < 0.004 vs. lean control;

  • P < 0.01 vs. lean control and pair-fed.