TABLE 2

Serum glucose and insulin values of sucrose-fed rats treated with or without metformin, before and during euglycemic-hyperinsulinemic clamps

GroupFasting glucose (mg/dl)Fasting insulin (μU/ml)Clamp glucose (mg/dl)Clamp insulin (μU/ml)GIR (mg/kg/min)
Sucrose135 ± 292 ± 8123 ± 8247 ± 4314.5 ± 1.1
Sucrose + metformin132 ± 558 ± 2*117 ± 6244 ± 3420.0 ± 2.2*
  • Data are means ± SE; n = 4 animals/group. For fasting values, rats were fasted ∼6–8 h before serum collection.

  • *

    * P < 0.05 vs. sucrose group.