TABLE 1

Glycemia, platelet aggregation, and tissue levels of AGEs during alloxan diabetes of 5 years’ duration

nHbA1 (%)Blood glucose (fasting; mg/dl)Glycosuria (g · day−1 · kg body wt−1)Platelet aggregation (% of max)Pentosidine
Protein-bound AGE
Aorta (U/mg protein)Tail collagen (pmol/mg protein)Hb-AGE (U/mg Hb)Aorta-AGE (U/mg protein)
Normal85.8 ± 0.270 ± 50 ± 070 ± 2319 ± 36.2 ± 1.81.8 ± 0.319 ± 3
Diabetes
 Control87.7 ± 0.4160 ± 372.9 ± 0.372 ± 1726 ± 410.4 ± 2.92.7 ± 0.726 ± 4
 + Aminoguanidine97.7 ± 0.4148 ± 293.0 ± 0.524 ± 29.9 ± 3.22.5 ± 0.424 ± 2
 + Aspirin87.8 ± 0.2161 ± 532.7 ± 0.43 ± 129 ± 811.2 ± 1.529 ± 8
  • Data are n or means ± SD.