TABLE 3

Effect of aminoguanidine and aspirin on kidney and nerve

Kidney weight (g/kg initial body wt)Glomerular volume (μm3 × 106)Silver-stained mesangium + matrix (% of glomerulus)Albumin excretion (mg/24 h)Nerve conduction velocity (year 5)
(m/sec)% of baseline
Normal2.7 ± 0.11.0 ± 0.152 ± 126 ± 564 ± 199 ± 3
Diabetes
 Control3.2 ± 0.22.6 ± 0.960 ± 470 ± 11658 ± 290 ± 3
 + Aminoguanidine3.4 ± 0.42.3 ± 0.864 ± 5163 ± 14860 ± 294 ± 3
 + Aspirin3.5 ± 0.32.4 ± 0.756 ± 543 ± 3658 ± 390 ± 5
  • Data are means ± SD.