TABLE 1

Parameters calculated from the seven-sample intravenous glucose test and estimated by the minimal model

ParameterControlsLI–IGF-I−/−
n1011
KG (% min−1)2.11 ± 0.272.87 ± 0.32
AIR (nmol/l)0.63 ± 0.111.67 ± 0.17*
AUCins (nmol/l in 50 min)7.1 ± 2.418.8 ± 3.1**
SI (10−4 · min−1 · pmol/l−1)1.25 ± 0.250.64 ± 0.15**
SG (min−1)0.052 ± 0.0130.063 ± 0.011
GDI16.1 ± 0.913.9 ± 1.3
  • Data are means ± SEM. The samples were obtained from pooled male and female mice at 4 months of age. Statistical evaluation was performed by Student’s t test. Asterisks indicate the probability level of random difference between the groups,

  • *

    * P < 0.01,

  • **

    ** P < 0.05). AUCins, area under the 50-min insulin curve.