TABLE 1

β-cell mass measurements in control and TG mice

Total β-cell mass/volumeTotal β-cell number (× 10−5)Mean β-cell volume (μm3)Total pancreas mass/volumeVolume-fraction of β-cells in pancreas (%)
Age 5 days
 PDX-1 TG (n = 8)0.14 ± 0.02 mm3NDND3.06 ± 0.55 mm34.7 ± 0.8
 Control (n = 8)0.15 ± 0.04 mm3NDND4.91 ± 1.01 mm33.2 ± 1.0
Age 6 weeks
 PDX-1 TG (n = 6)0.89 ± 0.14 mm3*6.2 ± 1.0*1408 ± 37*46.7 ± 5.5 mm31.9 ± 0.17
 Control (n = 8)0.93 ± 0.12 mm36.9 ± 0.81341 ± 47170.0 ± 11 mm30.54 ± 0.04
Age 8 months
 PDX-1 TG (n = 6)1.91 ± 0.26 mg*NDND86 ± 8 mg2.19 ± 0.18
 Control (n = 6)1.66 ± 0.18 mgNDND247 ± 10 mg0.67 ± 0.05
  • Data are means ± SE.

  • *

    * NS;

  • P < 0.005;

  • P < 0.0001; ND, not determined.