TABLE 1

Body and pancreas weights, plasma glucose and insulin levels, pancreatic insulin content, and β-cell mass of 7-day-old Wistar, n0-STZ, n0-STZ/GLP-1, and n0-STZ/Ex rats

Rats
Wistarn0-STZn0-STZ/GLP-1n0-STZ/Ex
Body weight (g)16.2 ± 0.3 (15)10.9 ± 0.3 (19)12.7 ± 0.3* (24)13.3 ± 0.7 (17)
Pancreas weight (mg)40.1 ± 1.5 (15)38.2 ± 1.4 (19)39 ± 1.1 (24)42 ± 1.5 (17)
Plasma glucose (mmol/l)7.1 ± 0.16 (15)12.8 ± 1.437.5 ± 0.24* (24)9.3 ± 0.10 (17)
Plasma insulin (pmol/l)195 ± 15 (15)270 ± 30 (19)135 ± 15* (24)300 ± 34 (17)
Pancreatic insulin
 μg/pancreas20.2 ± 0.6 (11)2.1 ± 0.3 (14)8.1 ± 0.8* (18)3.7 ± 0.3 (11)
 μg/g pancreas531 ± 23 (11)47 ± 7.1 (14)208 ± 21* (18)106 ± 11* (11)
β-Cell mass
 mg/pancreas0.76 ± 0.06 (4)0.16 ± 0.02 (5)0.39 ± 0.03* (4)0.54 ± 0.03* (4)
 μg/mg pancreas17.2 ± 1.1 (4)3.8 ± 0.4 (5)10.1 ± 0.6* (4)12.6 ± 0.9* (4)
  • Data are means ± SE (n). Animals were in the nonfasted state.

  • *

    * P < 0.001;

  • P < 0.01;

  • P < 0.05 compared with the untreated n0-STZ group.