TABLE 2

Body and pancreas weights, plasma glucose and insulin levels, pancreatic insulin content, and β-cell mass in 2-month-old Wistar, n0-STZ, n0-STZ/GLP-1, and n0-STZ/Ex female rats

Rats
Wistarn0-STZn0-STZ/GLP-1n0-STZ/Ex
Body weight (g)291 ± 4.5 (10)208 ± 5.9 (11)206 ± 6.7 (8)180 ± 3.0* (10)
Pancreas weight (mg)838 ± 29.5 (10)920 ± 39.6 (10)878 ± 62.6 (8)902 ± 38.2 (10)
Plasma glucose (mmol/l)6.9 ± 0.20 (12)9.7 ± 0.12 (12)7 ± 0.17 (10)6.1 ± 0.21 (12)
Plasma insulin (pmol/l)705 ± 61 (12)218 ± 43 (19)255 ± 18 (10)168 ± 13 (12)
Pancreatic insulin
 μg/pancreas83.6 ± 4.7 (10)44.5 ± 2.5 (11)57 ± 3.1 (8)59.9 ± 1.6 (10)
 μg/g pancreas99.5 ± 3.8 (11)48.7 ± 2.4 (14)65 ± 3.5 (8)67.6 ± 3.5 (10)
β-Cell mass
 mg/pancreas58.2 ± 0.1 (4)2.18 ± 0.16 (4)3.14 ± 0.15 (4)3.58 ± 0.3 (4)
 μg/mg pancreas7.90 ± 0.65 (4)2.85 ± 0.29 (4)3.66 ± 0.34 (4)4.45 ± 0.28 (4)
  • Data are means ± SE (n). Animals were in the fasted state.

  • *

    * P < 0.05;

  • P < 0.001;

  • P < 0.01 compared with the fasted state.