TABLE 1

HGU (mg · kg−1 · min−1), NHGO (mg · kg−1 · min−1), HGR (mg · kg−1 · min−1), and endogenous glucose production (Ra) and utilization (Rd) (mg · kg−1 · min−1) in 18-h–fasted conscious dogs

Time (min)−400306090120150180
HGU0.31 ± 0.130.27 ± 0.140.63 ± 0.06*0.19 ± 0.120.23 ± 0.110.48 ± 0.150.62 ± 0.160.65 ± 0.12*
NHGO1.96 ± 0.241.83 ± 0.150.98 ± 0.25*0.54 ± 0.23*0.46 ± 0.25*0.40 ± 0.20*0.41 ± 0.23*0.06 ± 0.22*
HGR2.28 ± 0.222.10 ± 0.161.60 ± 0.26*0.73 ± 0.32*0.70 ± 0.24*0.88 ± 0.29*1.03 ± 0.19*0.71 ± 0.23*
Ra2.61 ± 0.122.03 ± 0.161.91 ± 0.251.73 ± 0.25*1.51 ± 0.22*1.54 ± 0.22*1.32 ± 0.20*1.21 ± 0.20*
Rd2.61 ± 0.162.78 ± 0.133.20 ± 0.32*3.77 ± 0.55*4.03 ± 0.54*4.14 ± 0.55*3.98 ± 0.51*3.93 ± 0.51*
  • Data are means ± SE; n = 8;

  • *

    * P < 0.05 basal period (−40–0 min) vs. experimental period (intraportal 600 μU · kg−1 · min−1 insulin infusion; 0–180 min).