TABLE 4

Hepatic and whole body gluconeogenic GNG, glycogenolytic GLY, gluconeogenic-flux (GNG flux), and NHGLY rates (mg · kg−1 · min−1) measured using the AV difference, 14C-PEP, and 2H2O methods in four 18-h–fasted conscious dogs

14C-peptide (hepatic)
AV difference (hepatic)
2H2O (WB)
Basal period (−40 to 0 min)Last 30-min periodBasal period (−40 to 0 min)Last 30-min periodBasal period (−40 to 0 min)Last 30-min period
GNG0.78 ± 0.06*0.58 ± 0.181.41 ± 0.131.18 ± 0.17
GLY1.51 ± 0.09*0.49 ± 0.101.00 ± 0.190.40 ± 0.07
GNG flux0.95 ± 0.14*0.98 ± 0.180.98 ± 0.131.14 ± 0.16
NHGLY1.59 ± 0.21−0.08 ± 0.111.31 ± 0.18−0.25 ± 0.25*
GLY SYNNM0.70 ± 0.07
GLY DEGNM0.86 ± 0.13
  • Data are means ± SE; n = 4.

  • *

    * Data taken from Goldstein et al. (20) (n = 8); NM, not measured;

  • P < 0.05 basal vs. last 30 min (intraportal 600 μU · kg−1 · min−1 insulin infusion; 0–180 min).