TABLE 2

Comparison of the offspring of diabetic pregnancies and those whose mothers developed diabetes after pregnancy

Maternal diabetes during pregnancyYesNoP
n841
Age (years)22 ± 327 ± 60.03
Sex (M/F)4/424/170.7
Body fat (%)34 ± 833 ± 60.8
Mothers’ age at onset of diabetes (years)31 ± 634 ± 60.17
Glucose (mmol/l)
 Fasting4.8 ± 0.64.9 ± 0.60.8
 2-h6.4 ± 1.16.4 ± 0.60.8
Insulin (pmol/l)
 Fasting215 (155–300)220 (200–260)0.8
 2-h790 (510–1,240)910 (755–1,105)0.5
M (μmol/kg · metabolic  body size−1 · min−1)
Mlow15 (13–19)15 (14–16)0.6
Mhigh55 ± 650 ± 60.17
AIR (pmol/l)740 (510–1,310)1,255 (1,045–1,505)0.018
  • Data are means ± SD or geometric means (95% CI). M, glucose disposal rate at mean plasma insulin concentrations of 720 pmol/l (Mlow) and 13,800 pmol/l (Mhigh) expressed as micromole per kilogram of estimated metabolic body size (kg fat free mass + 17.7) per min. AIR, acute insulin response expressed as the mean of the change in plasma insulin levels relative to basal value from the 3rd to the 5th min after the intravenous glucose injection. AIR is adjusted for age, sex, percent body fat, Mlow, and age of onset of diabetes in the mother.