TABLE 2

Summary of microsatellite-based chromosomal maps of susceptibility and modifying QTL using KK mouse crosses

AuthorsCrosses of miceMale/female (n)Traits (age at evaluation)Locus (LOD score)
Suto et al. (9,10)(KKAy × C57BL/6)F249/44Fasting blood glucose levels (20 weeks)D6Mit268 (6.0)
D3Mit102 (2.8)
D5Mit113 (2.8)
Impaired glucose tolerance test (20 weeks)Not detected
Body weight (24 weeks)D4Mit1 (3.1)
Adiposity index (24 weeks)D10Mit95 (3.7)
Suto et al. (11)(KKAy × C57BL/6)F249/44Serum triglyceride levels (28 weeks)D9Mit163 (4.2)
Serum total cholesterol levels (28 weeks)D3Mit102 (4.3)
D1Mit150 (5.0)
Taylor et al. (12)(KK/H1L1 × C57BL/6)F2164/156Fasting blood glucose levels (16 weeks)D1Mit425 (3.6) male and female
Adiposity index (16 weeks)D9Mit66 (6.3) female
D9Mit66 (2.7) male
DXMit166 (5.0) male
Body weight (16 weeks)D7Mit350 (6.9) male and female
Present studyKK/Ta × (BALB/c × KK/Ta)F1 backcross208/0Fasting blood glucose levels (12 weeks)D12Mit4 (4.5)
D15Mit225 (3.3)
Impaired glucose tolerance test (20 weeks)D6Mit1 (4.0)
Serum insulin levels (20 weeks)D8Mit166 (2.2)
Serum triglyceride levels (20 weeks)D4Mit336 (3.2)
D8Mit166 (4.8)
Body weight (28 weeks)D4Mit336 (2.1)
Serum total cholesterol levels (20 weeks)D3Mit12 (4.0)