TABLE 1

Mean phenotypic values for parental strains, F1, and backcross mice

Ages (weeks)KK/Ta (n = 11)BALB/c (n = 11)(BALB/c × KK/Ta)F1 (n = 18)KK/Ta × (BALB/c × KK/Ta)F1 backcross (n = 193–208)
Body weight (g)2844.3 ± 0.8*29.2 ± 1.335.1 ± 1.732.1 ± 0.7
Fasting blood glucose levels (mg/dl)12122.7 ± 5.481.1 ± 3.273.6 ± 3.593.2 ± 1.6
Sum of blood glucose at 0 and 120 min (mg/dl)20548.5 ± 28.0148.5 ± 7.0195.2 ± 6.0249.5 ± 2.0
Sum of insulin levels at 0 and 120 min (mg/dl)205.2 ± 0.81.3 ± 0.31.7 ± 0.41.8 ± 0.1
Serum triglyceride levels (mg/dl)20134.8 ± 5.689.0 ± 5.669.2 ± 6.574.2 ± 1.8
Serum total cholesterol levels (mg/dl)20120.1 ± 4.094.0 ± 5.8100.3 ± 12.180.5 ± 1.6
  • Data expressed as means ± SE. Glucose levels were measured at 0 and 120 min after intraperitoneal glucose injection. Plasma insulin was measured at 0 and 120 min after glucose administration.

  • *

    * Significantly higher than that of BALB/c and F1 (P < 0.0001);

  • significantly higher than that of BALB/c and F1 (P < 0.001);

  • significantly higher than that of BALB/c (P < 0.0001).